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Adam Lerner is a 27-year-old public radio journalist in Seattle with an artist girlfriend Rachael, of whom his best friend and co-worker Kyle disapproves. Where Kyle is brash and outspoken, Adam is more introverted and mild-mannered. After experiencing harsh pains in his back, Adam learns from his doctor that he has schwannoma neurofibrosarcoma (a malignant tumor) in his spine, and must undergo chemotherapy. He sees on the Internet that his chances of survival are fifty-fifty.